Publicaciones – Página 2

Workflow Times and Outcomes in Patients Triaged for a Suspected Severe Stroke

García-Tornel Á, Seró L, Urra X, Cardona P, Zaragoza J, Krupinski J et al. Ann Neurol. 2022 Dec;92(6):931-942. doi: 10.1002/ana.26489. Epub 2022 Sep 7. PMID: 36053966

https://pubmed.ncbi.nlm.nih.gov/36053966/

Assessment of Regional Lung Ventilation with Positron Emission Tomography Using the Radiofluorinated Gas [18F]SF6: Application to an Animal Model of Impaired Ventilation

Passannante R, Gómez-Vallejo V, Cossío U, Ruiz-Cabello J, Lekuona A et al. Mol Imaging Biol. 2022 Sep 27. doi: 10.1007/s11307-022-01773-7. Online ahead of print. PMID: 36167904

https://pubmed.ncbi.nlm.nih.gov/36167904/

Neutrophil β1 adrenoceptor blockade blunts stroke-associated neuroinflammation

Clemente-Moragón A, Oliver E, Calle D, Cussó L, Gómez M, Pradillo JM et al. Br J Pharmacol. 2022 Sep 30. doi: 10.1111/bph.15963. Online ahead of print. PMID: 36181002

https://pubmed.ncbi.nlm.nih.gov/36181002/

Editorial: Understanding stroke recovery to improve outcomes: From acute care to chronic rehabilitation

Conforto AB, Liew SL, Luft AR, Kitago T, Bernhardt J, Arenillas JF. Front Neurol. 2022 Sep 27;13:1021033. doi: 10.3389/fneur.2022.1021033. eCollection 2022. PMID: 36237621

https://pubmed.ncbi.nlm.nih.gov/36237621/

Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

Cullell N, Soriano-Tárraga C, Gallego-Fábrega C, Cárcel-Márquez J, Muiño E, Llucià-Carol L, Lledós M, Esteller M, de Moura MC, Montaner J et al. Clin Epigenetics. 2022 Sep 30;14(1):124. doi: 10.1186/s13148-022-01340-5.PMID: 36180927

https://pubmed.ncbi.nlm.nih.gov/36180927/

Results: The meta-analysis revealed an epigenome-wide signifcant association in EXOC4 (p value=8.4× 10–08) and in MERTK (p value=1.56× 10–07). Only the methylation in EXOC4 was also associated in the Discovery and in the Replication Cohorts (p value=1.14× 10–06 and p value=1.3× 10–02, respectively). EXOC4 methylation negatively correlated with the long-term outcome (coefcient=−4.91) and showed a tendency towards a decrease in EXOC4 expression (rho=−0.469, p value=0.091). Pathway enrichment from the meta-analysis revealed signifcant associa‑tions related to the endocytosis and deubiquitination processes. Seventy-nine plasma proteins were diferentially expressed in association with EXOC4 methylation. Pathway analysis of these proteins showed an enrichment in natural killer (NK) cell activation. The cell-type methylation analysis in blood also revealed a diferential methylation in NK cells.

Acknowledgements: We thank the International Stroke Genetics Consortium, the Spanish Stroke Genetics Consortium, the International Stroke Genetics Consor‑tium, the Global Alliance for Stroke acute and long-term outcome, RETICS Network INVICTUS (RD16/0019/0002, RD16/0019/0010, RD16/0019/0011, RD16/0019/0021) and the RICORS Stroke network.