Publicaciones
Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion
International controlled study of revascularization and outcomes following COVID-positive mechanical thrombectomy
Treatment with natalizumab during pregnancy in multiple sclerosis: The experience of implementing a clinical practice protocol (NAP-30)
Valero-López G, Millán-Pascual J, Iniesta-Martínez F et al. Mult Scler Relat Disord. 2022 Oct;66:104038. doi: 10.1016/j.msard.2022.104038. Epub 2022 Jul 7. PMID: 35870370
Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia
Int J Mol Sci. 2022 Jul 22;23(15):8093. doi: 10.3390/ijms23158093. PMID: 35897671
https://pubmed.ncbi.nlm.nih.gov/35897671/
Abstract: After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performed transient middle cerebral artery occlusion (MCAO) and sham surgery on C57BL/6J mice and collected bronchoalveolar lavage fluid (BALF), serum, brain, and lung homogenate samples 24 h after surgery. A 92 proteins-panel developed by Olink Proteomics® was used to analyze the content in BALF and lung homogenates. MCAO animals had higher protein concentration levels in BALF than sham-controls, but these levels did not correlate with the infarct volume. No alteration in alveolar-capillary barrier permeability was observed. A total of 12 and 14 proteins were differentially expressed between the groups (FDR < 0.1)
in BALF and lung tissue homogenates, respectively. Of those, HGF, TGF-α, and CCL2 were identified as the most relevant to this study. Their protein expression patterns were verified by ELISA. This study confirmed that post-stroke lung damage was not associated with increased lung permeability or cerebral ischemia severity. Furthermore, the dysregulation of HGF, TGF-α, and CCL2 in BALF and lung tissue after ischemia could play an important role in the molecular mechanisms underlying stroke-induced lung damage.
This project received funding from: Instituto de Salud Carlos III (ISCIII) [PI17/02130, PI21/00939], co-financed by the European Regional Development Fund (FEDER), from the Fundació La Marató de TV3 [201706]. The participating centers take part into RICORS-ICTUS network [RD21/0006/0024, RD21/0006/0007, RD21/0006/0015] from Instituto de Salud Carlos III (ISCIII)
[PI17/02130, PI21/00939], co-financed by the European Regional Development Fund (FEDER). The funders had no role in designing or executing this study
Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Development of a Score to Predict the Paroxysmal Atrial Fibrillation in Stroke Patients: The Screening for Atrial Fibrillation Scale
more thorough etiological evaluation. External validation of SAFE in a multicenter study, with a larger number of patients, is warranted.
Intra-arterial Alteplase vs Placebo After Successful Thrombectomy and Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke-Reply
JAMA. 2022 Jun 28;327(24):2456. doi: 10.1001/jama.2022.7430. PMID: 35763000
Surrogate biomarkers of outcome for wake-up ischemic stroke
BMC Neurol. 2022 Jun 9;22(1):215. doi: 10.1186/s12883-022-02740-z.PMID: 35681147
Connectomic-genetic signatures in the cerebral small vessel disease
Neurobiol Dis. 2022 Jun 1;167:105671. doi: 10.1016/j.nbd.2022.105671. Epub 2022 Feb 26.PMID: 35231560